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The last proposed system of RBC vasodilation during the existence of nitrite is the reduction of nitrite to NO by Hb. Brooks first analyzed the nitrite Hb conversation in 1937 and this get the job done was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to variety metHb and NO (Brooks, 1937; D